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M9480124.TXT
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1994-08-09
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Document 0124
DOCN M9480124
TI High rate of nonspecific anti-hepatitis C reactivity amongst homosexual
men in comparison with that found in other sexually active groups and
blood donors. Viral Hepatitis and AIDS Study Group.
DT 9410
AU Andreu J; Abad MA; Sanchez-Quijano A; Torronteras R; Luque F; Garcia de
las Heras J; Soto B; Pineda JA; Leal M; Lissen E; Department of Internal
Medicine, Virgen del Rocio University; Hospital, Seville, Spain.
SO J Intern Med. 1994 Jul;236(1):73-7. Unique Identifier : AIDSLINE
MED/94292895
AB OBJECTIVES. To investigate the concordance of anti-hepatitis C virus
(anti-HCV) reactivity by a second-generation enzyme immunoassay (EIA-2)
and by a four-antigen recombinant immunoblot assay (4-RIBA) in
homosexual men, in comparison with that found in other sexually active
groups and blood donors. DESIGN. Prospective study. SETTING. Tertiary
referral centre, Seville, Spain. SUBJECTS. A total of 1203 subjects were
studied. Eight hundred and three were sexually active individuals: 547
female prostitutes, 88 heterosexual men who had frequent sexual
intercourse with prostitutes, and 168 homosexual men. All of them denied
blood transfusion and parenteral drug use. In addition, 400 voluntary
blood donors were selected at random. MAIN OUTCOME MEASURES. All serum
samples were screened for anti-HCV by EIA-2 and repeatedly reactive sera
were tested by 4-RIBA. Homosexual men were also screened for anti-human
immunodeficiency virus (anti-HIV), hepatitis B virus (HBV) markers and
gammaglobulin concentration. Finally, serum samples from homosexual men
reactive for anti-HCV by EIA-2 were analyzed for HCV-RNA by polymerase
chain reaction (PCR). RESULTS. Concordance between EIA-2 and 4-RIBA in
female prostitutes (71.4%), clients of prostitutes (75.0%), and blood
donors (83.3%) was significantly higher than in homosexual men (38.8%)
(P < 0.04). In this collective the concordance between 4-RIBA and PCR
was 85.7% for positive cases and 88.8% for negative ones, and EIA-2
ratios in reactive sera were significantly higher in 4-RIBA confirmed
cases (P < 0.0001). No correlation between false positive EIA-2 results
and presence of HIV infection, HBV markers or hypergammaglobulinaemia
was found in homosexual men by univariate analysis. CONCLUSIONS. There
is a high level of non-specific anti-HCV reactivity by EIA-2 amongst
homosexual men in comparison with that found in other sexually active
groups and blood donors. The true prevalence of HCV infection amongst
homosexual men could be even lower than previously described.
DE Adult Analysis of Variance Antigens, Viral/*BLOOD *Blood Donors
Comparative Study Female Gamma Globulins/ANALYSIS Hepatitis B
Antigens/BLOOD Hepatitis C/EPIDEMIOLOGY Hepatitis C
Viruses/*IMMUNOLOGY *Homosexuality Human HIV Antigens/BLOOD
Immunoenzyme Techniques Male Middle Age Prevalence *Prostitution
JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).